Exercise decrease the expression of MCP-1 in perivascular adipose tissue (PVAT) in obese mice

Introduction: Exercise has been believed to prevent metabolic syndrome (Mets) from occurring. Accumulation of inflammation factors such as monocytes chemoattractant protein-1 (MCP1) in adipose tissue is a factor the development MetS. However, inflammatory mediators that play role accumulation macrophages are still unclear, so this study aims determine expression MCP-1 perivascular (PVAT). Methods: Eight-week-old male wild-type mice, were divided into five groups. One control group was given standard diet and four groups high-fat (HFD) for 2 weeks. treatment HFD by dividing with exercise once week, three times week. As exercise, speed 10-18m/minute 30 minutes. carried out two Gene PVAT tissues analyzed using quantitative chain reaction (PCR). Results: The experienced an increase body weight (P <0.01) mass compared group. Furthermore, decreased <0.05) HFD-Exc1 <0.01). tends decrease mediator Conclusion: These results suggested partially reduces adiposity, tended decreases HFD-induced obesity.